Comparison of cross-reactivity of antibodies elicited by infection D614G, Beta, Delta, BA.1, and BA.4 infection in previously unvaccinated individuals. Fold decrease in (A) neutralization and (B) ADCC potential for each VOC represented as a ratio of the titer against the infecting variant (D614G, Beta, Delta, BA.1, and BA.4/5) over that titer against unmatched VOCs. Shown are geometric means of the ratios, with error bars denoting the 95% CI. All data are representative of two independent experiments. Median days post-infection for each group in indicated in italics with ranges indicated in brackets.