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. Author manuscript; available in PMC: 2024 Jul 23.
Published in final edited form as: FASEB J. 2023 Mar;37(3):e22825. doi: 10.1096/fj.202201972RR

FIGURE 1.

FIGURE 1

Elevated NAMPT hepatic expression in human subjects with NAFLD. (A) Normal liver tissue showing hepatocytes without steatosis (Human Normal). NAFLD liver tissue showing macrovesicular steatosis (long arrow), hepatocyte ballooning (short arrow), and focal lobular inflammation (arrowhead) (Human NAFLD) (bar—50 μm). (B) Semi-quantification of steatosis in hepatocytes showing significantly higher percentages of hepatocytes involved with lipid accumulation in NAFLD livers compared with normal livers. (C) Immunohistochemistry (IHC) for NAMPT showed mild positivity (arrow) in normal liver tissue (Human Normal), but strong positivity (arrows) in liver with NAFLD (Human NAFLD). (D) Image J software semi-quantitation of NAMPT immunostaining intensity represented as mean gray value confirmed significantly higher NAMPT staining in human NAFLD liver tissues compared to normal liver tissues (p < .05, n = 5) (bar—20 μm).