Table 2.
Summary of Olopatadine Partition Coefficients and Effective Diffusivities in Both Control and Vitamin-E Modified ACUVUE OASYS and ACUVUE TruEye Lenses
| Contact lens | Total drug into/from the lens matrix (μg) |
|
|||
|---|---|---|---|---|---|
| Uptake | Release | Water content (%) | Partition coefficient | Effective diffusivity ( × 10−5 mm2/h) | |
| 1-DAY ACUVUE TruEye® | — | 36.25 ± 2.2 | 46.1 ± 0.2 | 0.78 ± 0.1 | 8.44 |
| 1-DAY ACUVUE TruEye (with 10% VE) | — | 37.86 ± 1.7 | 45.5 ± 0.9 | 0.84 ± 0.09 | 2.53 |
| 1-DAY ACUVUE TruEye (with 20% VE) | — | 26.09 ± 0.8 | 42.8 ± 0.4 | 0.59 ± 0.05 | 2.31 |
| 1-DAY ACUVUE TruEye (with 30% VE) | — | 20.66 ± 3.1 | 40.1 ± 0.2 | 0.50 ± 0.1 | 0.65 |
| ACUVUE OASYS | — | 29.28 ± 0.9 | 37.9 ± 0.2 | 0.63 ± 0.09 | 48.7 |
| ACUVUE OASYS (with 10% VE) | — | 30.50 ± 1.6 | 34.2 ± 0.1 | 0.70 ± 0.08 | 9.65 |
| ACUVUE OASYS (with 20% VE) | — | 36.45 ± 4.3 | 31.8 ± 1.1 | 0.90 ± 0.07 | 1.12 |
| ACUVUE OASYS (with 30% VE) | — | 28.17 ± 0.7 | 30.9 ± 0.6 | 0.63 ± 0.1 | 0.37 |
Data are presented as mean ± SD with “N = 3”.
SD, standard deviation.