Fig 5. Pre-administration of metformin significantly reduces the number of micronuclei in bone marrow cells and mitigates DNA damage in colon and lung tissues, after exposure to the 75 cGy 33-beam GCRsim irradiated mice.

(A) Pre-administration of metformin chow 200 mg/kg decreases the number of MN in murine bone marrow cells, GCRsim irradiated. (B, C) Metformin pre-treatment decreases the number of 53BP1 positive cells significantly in colon and lung tissues of irradiated wild type mice (one-way ANOVA, *p<0.5, **p<0.01).