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(A, B) Pre-administration of metformin chow 200 mg/kg in 129/sv mice, retains the expression of OGG1. (C, D) Furthermore, metformin significantly decreases the expression of cleaved PARP, compared to the irradiated control. (E, F) Metformin activates AMPK through the phosphorylation at Thr 172 (One-way ANOVA, *p<0.05, ** p<0.01, ***p<0.001, **** p<0.0001).
