Fig 1. Macrophage pathogenesis phenotypes of S. aureus lineages from individuals with CF over time and phylogenetically matched control strains.

Phenotypes of S. aureus strains isolated from respiratory cultures of individuals with CF at the time of initial isolation during serial surveillance are compared to the last-collected strains from same patient, and to phylogeny-matched strains from unaffected controls. Measures of macrophage invasion, relative to in-batch testing of the JE2 control strain (A), and macrophage intracellular survival (B) are separately reported. Statistical significance was assessed using paired two-tailed T tests.