(A,B&C) mRNA expression of brain substantia nigra HO-1, GCLM, and NQO1 in various subgroups. (D&F-I) Nuclear and cytoplasmic protein expression of Nrf2 in substantia nigra and striatum of each group. D: Protein expression profiles of nuclear and cytoplasmic Nrf2, F-I: Relative expression levels of nuclear and cytoplasmic Nrf2 proteins, SN: Substantia Nigra, Str: Striatum. (E&J-O) Expression of Nrf2 downstream proteins in substantia nigra and striatum of each group. E: Protein expression profiles of downstream proteins of Nrf2 in the substantia nigra and striatum, J-O: Relative expression levels of downstream proteins of Nrf2 in the substantia nigra and striatum, SN: Substantia Nigra, Str: Striatum, *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.