FIG. 1.

Domains and processed products of the MHV gene 1 polyprotein. Predicted MHV functional domains indicated here were identified by amino acid sequence homology to known viral functional domains (22, 29). Abbreviations: PCP, papain-like cysteine protease; 3Cpro, poliovirus 3C-like protease; MP, membrane-associated protein; HEL, helicase; POL, polymerase. Regions used to generate fusion proteins and ultimately rabbit polyclonal antisera are indicated under the amino acid scale. The processing of ORF 1a products depicted here is based on previous findings (2, 6, 12, 13, 20, 33, 34, 45, 48) and results shown in Fig. 5 and is slightly different from that reported by Denison et al. (15). The dashed lines represent products of uncertain nature.