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. 2024 Apr 3;48(2):91–111. doi: 10.55730/1300-0152.2686

Figure 2.

Figure 2

The ERCC1-XPF protein-protein interaction (PPI) complex, (PDB ID: 1Z00) is depicted in this illustration, showcasing ligands bound to three distinct binding sites and the interacting amino acid residues. (a) Binding site 1 comprises a set of residues on the XPF protein, including Tyr833, Asn834, Pro837, Gln838, Met856, Lys860, Asn861, and Ile862, which engage in interactions with corresponding residues 292–294 on the ERCC1 protein. (b) Binding site 2 involves specific residues on the XPF protein, namely Asp839, Phe840, Lys843, Pro845, and Ala863, which interact with residues Arg234, Cys238, and Thr241 on the ERCC1 protein. (c) Binding site 3 encompasses a group of residues on the XPF protein, consisting of Asp888, Phe889, Thr892, Ser893, Phe894, Ala895, Val898, and Gly901. These residues interact with the ERCC1 residues Phe231, Val232, Val235, Leu254, Gly258, Ser259, Leu260, and Glu261. This visual representation was generated using ChimeraX.