Table 1.
Meta-regression of HLA association effects in imputed anti-NMDAR cases vs. controls analyzed using a Generalized Linear Equation modeling after control of first three intra-ethnic Principal Components.
| Allele | Estimation | Standard Error | Min | Max | Cases (n=412)* | Controls (n=2784)* | Effect | Std. Error | Estimated OR | P-value** | Direction*** | Heterozygosity P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DRB3*03:01 | 5.107 | 4.610 | 2.353 | 17.647 | 4.497 (21) | 9.355 (251) | -0.973 | 0.280 | 0.38 | 2.05E-03 | —— | 0.7340 |
| DRB1*11:01 | 22.949 | 3.394 | 18.182 | 28.916 | 21.888 (102) | 15.692 (416) | 0.471 | 0.139 | 1.60 | 3.05E-02 | ++++++ | 0.7291 |
| DQA1*01:01 | 26.508 | 8.044 | 15.294 | 37.647 | 23.431 (112) | 18.599 (494) | 0.415 | 0.137 | 1.51 | 3.88E-02 | +++-+- | 0.0011 |
| DRB1*13:02 | 4.457 | 4.249 | 1.205 | 18.182 | 4.292 (20) | 8.714 (231) | -0.935 | 0.307 | 0.39 | 4.79E-02 | —— | 0.8476 |
| DRB1*01:01 | 22.512 | 7.057 | 0.000 | 32.530 | 18.670 (87) | 15.504 (411) | 0.450 | 0.153 | 1.57 | 4.79E-02 | -++-+- | 0.0004 |
| DQB1*05:01 | 29.377 | 9.378 | 15.385 | 42.353 | 26.543 (129) | 21.632 (599) | 0.374 | 0.1305 | 1.45 | 7.47E-02 | +++-+- | 0.0040 |
*Cases and controls with imputation probability < 0.3 were excluded from the meta-analysis.
**FDR corrected.
***Cohort order: African in Affymetrix, East Asian in Affymetrix, European in Affymetrix, European in Illumina, European in PMRA, European in PMRA (replication), non-European in PMRA (replication); “+”: increased in cases, “-”: decreased in cases.