Table 2.

Meta-regression of Additive Count Number Variation effects in all cases and controls, analyzed using General Linear Regression modelling after control of first three intra-ethnic Principal Components.

Allele	Effect	Std. Error	P-value	P-value FDR corrected	Direction*	Heterogeneity P-value
KIR2DL3	-0.055	0.040	0.1743	0.3835	—+	0.9663
KIR2DS3T	0.022	0.017	0.2016	0.4032	?+-++	0.7370
KIR2DL1	0.024	0.033	0.4665	0.6842	++–+	0.8283
KIR2DL2	0.055	0.040	0.1719	0.3835	++++-	0.9571
KIR2DS4Del	-0.002	0.044	0.9714	0.9714	+–+-	0.8354
KIR2DL5	0.037	0.050	0.4628	0.6842	++—	0.7386
KIR3DL2	N/A	N/A	N/A	N/A	N/A	N/A
KIR2DP1	0.009	0.033	0.7786	0.9714	-+–+	0.7344
KIR2DL5B	0.101	0.028	0.0003	0.0056	+++–	0.1845
KIR2DL4	0.041	0.016	0.0108	0.1191	-++++	0.2680
KIR3DL3	N/A	N/A	N/A	N/A	N/A	N/A
KIR2DS3	0.054	0.037	0.1459	0.3835	++—	0.7279
KIR2DS3C	0.044	0.031	0.1511	0.3835	+++–	0.8106
KIR2DS5	-0.006	0.033	0.8523	0.9714	+—	0.9992
KIR2DS1	-0.041	0.034	0.2214	0.4059	+—	0.5479
KIR3DS1	0.003	0.030	0.9148	0.9714	+—+	0.7697
KIR3DL1	0.056	0.036	0.1182	0.3835	+++++	0.9586
KIR2DS4wt	0.055	0.039	0.1558	0.3835	-++-+	0.5115
KIR2DS2	0.058	0.040	0.1439	0.3835	++++-	0.8043
KIR2DS5C	0.011	0.007	0.1234	0.3835	-+—	0.6663
KIR2DS5T	0.005	0.028	0.8687	0.9714	+-+-+	0.7893
KIR2DL5A	-0.031	0.034	0.3713	0.6284	+—+	0.5406

N/A, not applicable.

*Order of cohorts: African, European, Asian, African-European, Asian-European; “+”, increased in cases; “-”, decreased in cases; “?”, not examined in cohort and thus has a smaller corresponding weight.

Bold values means significant.