Table 4.
Gene expression analysis between CD56bright and CD56dim NK cells using Generalized Linear Models and controlling for Age and Sex.
| Gene | CD56bright vs. CD56dim | Cases vs. Controls | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Intercept | Beta | P-value* | CD56bright | CD56dim | Intercept | Beta | P-value* | Controls | Long-term treatment | Short-term treatment | No treatment | |
| NKG7 | 38972 | -08639 | 134E-09 | 3.166 ± 0.504 | 4.028 ± 0.313 | 4009 | -0196 | 153E-04 | 4.135 ± 0.221 | 3.903 ± 0.080 | 3.713 ± 0.286 | 3.577 ± 0.325 |
| NCAM1 (CD56) | 01240 | 02777 | 421E-09 | 0.423 ± 0.195 | 0.145 ± 0.064 | 0178 | -0033 | 153E-02 | 0.206 ± 0.063 | 0.160 ± 0.063 | 0.161 ± 0.085 | 0.113 ± 0.075 |
| FCGR3A (CD16) | 06225 | -04943 | 172E-07 | 0.085 ± 0.143 | 0.580 ± 0.386 | 0691 | -0199 | 248E-03 | 0.751 ± 0.365 | 0.388 ± 0.181 | 0.265 ± 0.182 | 0.270 ± 0.119 |
| KLRC1 (KLRC1) | 02479 | 05604 | 111E-05 | 0.906 ± 0.542 | 0.344 ± 0.218 | 0512 | -0103 | 218E-02 | 0.495 ± 0.245 | 0.319 ± 0.131 | 0.364 ± 0.232 | 0.172 ± 0.131 |
| NCR3 (CD337) | 04770 | -02598 | 489E-05 | 0.233 ± 0.190 | 0.492 ± 0.229 | 0495 | -0081 | 481E-02 | 0.534 ± 0.145 | 0.383 ± 0.142 | 0.499 ± 0.378 | 0.276 ± 0.127 |
| KIR2DL1 | 01049 | -00689 | 534E-05 | 0.026 ± 0.053 | 0.095 ± 0.064 | 0123 | -0012 | 261E-01 | 0.097 ± 0.051 | 0.073 ± 0.041 | 0.085 ± 0.079 | 0.084 ± 0.095 |
| KLRC3 (NKG2E) | 01552 | 02564 | 534E-05 | 0.453 ± 0.271 | 0.195 ± 0.125 | 0238 | -0025 | 369E-01 | 0.239 ± 0.119 | 0.200 ± 0.158 | 0.211 ± 0.174 | 0.164 ± 0.078 |
| B3GAT1 (CD57) | 00134 | -00165 | 124E-04 | 0.000 ± 0.000 | 0.016 ± 0.020 | 0015 | -0007 | 438E-02 | 0.024 ± 0.022 | 0.009 ± 0.008 | 0.005 ± 0.011 | 0.006 ± 0.008 |
| KIR2DL3 | 00814 | -00531 | 151E-03 | 0.027 ± 0.057 | 0.081 ± 0.056 | 0086 | -0011 | 302E-01 | 0.082 ± 0.054 | 0.065 ± 0.028 | 0.083 ± 0.056 | 0.042 ± 0.043 |
| KIR3DL2 | 01160 | -00590 | 151E-03 | 0.033 ± 0.066 | 0.092 ± 0.064 | 0098 | 0010 | 398E-01 | 0.081 ± 0.062 | 0.084 ± 0.061 | 0.095 ± 0.076 | 0.098 ± 0.050 |
| KLRC2 | 02395 | 02400 | 151E-03 | 0.453 ± 0.328 | 0.213 ± 0.160 | 0302 | -0029 | 393E-01 | 0.277 ± 0.187 | 0.181 ± 0.121 | 0.205 ± 0.138 | 0.239 ± 0.239 |
| KIR2DL4 | 00953 | 00955 | 206E-03 | 0.133 ± 0.156 | 0.038 ± 0.024 | 0085 | -0005 | 398E-01 | 0.055 ± 0.044 | 0.050 ± 0.022 | 0.039 ± 0.016 | 0.055 ± 0.052 |
| GNLY | 45563 | 03235 | 992E-03 | 4.735 ± 0.366 | 4.415 ± 0.530 | 4740 | -0033 | 713E-01 | 4.546 ± 0.402 | 4.389 ± 0.447 | 4.195 ± 0.769 | 4.534 ± 0.304 |
| KIR3DL1 | 00595 | -00631 | 992E-03 | 0.029 ± 0.109 | 0.091 ± 0.079 | 0075 | -0019 | 141E-01 | 0.089 ± 0.080 | 0.095 ± 0.059 | 0.085 ± 0.103 | 0.049 ± 0.048 |
| KLRG1 | 01179 | -00761 | 992E-03 | 0.086 ± 0.110 | 0.161 ± 0.099 | 0150 | -0035 | 483E-02 | 0.190 ± 0.108 | 0.132 ± 0.070 | 0.128 ± 0.069 | 0.077 ± 0.062 |
| KLRB1 (CD161) | 20964 | -02592 | 471E-02 | 1.981 ± 0.616 | 2.239 ± 0.297 | 2168 | -0139 | 614E-03 | 2.331 ± 0.176 | 2.235 ± 0.144 | 2.067 ± 0.388 | 1.873 ± 0.363 |
| KLRK1 (NKG2D) | 06562 | 01177 | 259E-01 | 0.791 ± 0.393 | 0.674 ± 0.289 | 0912 | -0208 | 225E-05 | 0.910 ± 0.178 | 0.519 ± 0.154 | 0.487 ± 0.256 | 0.342 ± 0.082 |
| NCR1 | 01156 | -00221 | 549E-01 | 0.114 ± 0.135 | 0.136 ± 0.073 | 0147 | -0030 | 382E-02 | 0.154 ± 0.059 | 0.137 ± 0.054 | 0.131 ± 0.109 | 0.053 ± 0.048 |
| CD7 | 19797 | -00354 | 836E-01 | 1.906 ± 0.457 | 1.941 ± 0.249 | 1979 | 0041 | 393E-01 | 1.881 ± 0.211 | 1.975 ± 0.221 | 2.018 ± 0.393 | 2.048 ± 0.161 |
| KLRC4 (NKG2F) | 01007 | 00054 | 847E-01 | 0.096 ± 0.110 | 0.091 ± 0.062 | 0113 | -0033 | 153E-03 | 0.127 ± 0.037 | 0.047 ± 0.024 | 0.088 ± 0.083 | 0.032 ± 0.028 |
| KLRD1 (CD94) | 13727 | 00430 | 847E-01 | 1.378 ± 0.576 | 1.336 ± 0.460 | 1700 | -0318 | 474E-05 | 1.648 ± 0.335 | 1.219 ± 0.130 | 1.113 ± 0.426 | 0.671 ± 0.304 |
| KLRF1 | 07242 | -00258 | 847E-01 | 0.888 ± 0.363 | 0.910 ± 0.384 | 0922 | -0176 | 122E-02 | 1.092 ± 0.384 | 0.754 ± 0.245 | 0.815 ± 0.304 | 0.582 ± 0.225 |
| KIR3DL3 | 00007 | 431E-05 | 966E-01 | 0.001 ± 0.005 | 0.001 ± 0.003 | 0002 | 0000 | 734E-01 | 0.000 ± 0.001 | 0.003 ± 0.006 | 0.000 ± 0.000 | 0.000 ± 0.000 |
*P-values FDR corrected for multiple comparisons. Covariates not shown due to lack of significance. Mean of means shown.