TABLE 2.
Stability of Q808 in Rhesus monkey plasma under various storage conditions (data was processed based on an assay of triplicate prepared QC samples at three concentrations, n = 3).
| Storage conditions | Spiked conc. (ng/mL) | Calculated conc. (ng/mL) | R.E. (%) |
|---|---|---|---|
| (mean ± SD, n = 3) | |||
| In plasma at −80°C for 30 days | 2.5 | 2.5 ± 0.2 | −0.1 |
| 22.5 | 20.1 ± 1.0 | −10.7 | |
| 600 | 545 ± 9.9 | −9.2 | |
| In plasma after three/thaw cycles | 2.5 | 2.4 ± 0.3 | −5.9 |
| 22.5 | 22.1 ± 0.8 | −1.8 | |
| 600 | 561 ± 7.0 | −6.5 | |
| In plasma at room temperature for 4 h | 2.5 | 2.6 ± 0.2 | 2.5 |
| 22.5 | 24.3 ± 0.9 | 8 | |
| 600 | 586 ± 26.3 | −2.2 | |
| In processed samples at room temperature for 6 h | 2.5 | 2.5 ± 0.3 | −2 |
| 22.5 | 21.9 ± 2.9 | −2.8 | |
| 600 | 652 ± 11.4 | 8.7 |