TABLE 4.
Pharmacokinetic (PK) properties of Q808 after single IV bolus of 6.44 mg/kg.
| PK parameter | Dosage (mg) | t-test vs. 6.44 mg/kg single oral dose (p-Value) |
|---|---|---|
| 6.44 mg/kg | ||
| No. | 6 | |
| Tmax, median (min–max), min | 1.00 (1.00–1.00) | 0.0022 |
| Cmax, mean (SD), ng/mL | 21,816.67 (658.53) | <0.0001 |
| AUC0-t, mean (SD), h*ng/mL | 17,131.50 (5,225.89) | 0.0012 |
| AUC0−∞, mean (SD), h*ng/mL | 17,758.83 (5,492.25) | 0.0013 |
| T1/2, mean (SD), h | 7.58 (2.20) | 0.1127 |
| Vd, mean (SD), mL | 4,129.67 (1128.37) | 0.0042 |
| CL, mean (SD), mL/h/kg | 394.50 (127.59) | 0.0008 |
| MRT, mean (SD), h | 8.90 (2.87) | 0.0004 |
Abbreviations: SD, standard deviation; Tmax, time to peak plasma concentration; Cmax, peak plasma concentration; AUC, area under the plasma concentration; T1/2, terminal elimination halt-life; Vd, apparent volume of distribution; CL, apparent clearance; MRT, mean residence time.