Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jul 10;18:1428146. doi: 10.3389/fnbeh.2024.1428146

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Canonica, Kidd, Gibbins, Lana-Elola, Fisher, Tybulewicz and Good.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Altered abundance of glutamate receptor subunits in HPC synaptosomes from Dp1Tyb, Dp(17)3Yey, and Dp(10)2Yey male mice. (A–C) HPC synaptosomes from the indicated mouse strains were analyzed by immunoblotting for glutamate receptor subunits and PSD95. Example immunoblots are shown on the left and mean ± SEM protein abundance on the right, normalized to β-actin (or to GluA1 or GluN2B in case of phosphorylation levels of the respective receptor) and then to the mean signal in WT mice. Immunoblots show analysis of HPC synaptosome extracts from 2 to 5 mice of each genotype. Compared to WT littermates, mutant Dp1Tyb mice displayed lower hippocampal expression of GluA1, pGluA1(S845), and PSD95 (Student’s t-test, *p < 0.05) (A). Mutant Dp(10)2Yey mice displayed an age-dependent decrease in hippocampal expression of GluK5 and PSD95 compared to WT littermates (two-way ANOVA, *p < 0.05, **p < 0.001) (C). The decrease in GluK5 expression was not driven by age-dependent changes in the WT group as this comparison was not statistically significant (p > 0.05) (C). 21-month-old Dp1Tyb: n = 6 WT, 5 Dp1Tyb; 21-month-old Dp(17)3Yey: n = 9 WT, 12 Dp(17)3Yey; 14-month-old Dp(10)2Yey: n = 9 WT, 11 Dp(10)2Yey; 22-month-old Dp(10)2Yey: n = 6 WT, 10 Dp(10)2Yey.