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. 2024 Jul 10;15:1433664. doi: 10.3389/fmicb.2024.1433664

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Copyright © 2024 Fan, Xi, Liu, Song, Zhao, Zhou, Zou, Fu, Li, Jia and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibitory activity of myricetin on mutant TGEV PLpro. (A) The mutant plasmid DNA sequencing results are arranged from left to right as follows; C102A, R252A, and H255A respectively. The results showed that all three mutation sites were alanine. (B) Identification of pRSFDuet-1-PLpro recombinant plasmid for TGEV PLpro. M: 5 kb DNA Marker. (C) Recombinant PLpro western blot results. (D) Inhibition rate of myricetin on TGEV PLpro mutant protein. C102A mutation can increase the relative enzyme activity of PLpro.