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. 2024 Jul 10;15:1384070. doi: 10.3389/fphar.2024.1384070

FIGURE 6.

FIGURE 6

Representative mechanical recordings from the circular muscle showing the effect of peppermint oil (1–1,000 μg/mL) and HBB (10–7 to 10–5 M) on spontaneous phasic contractions (A), cch (10–5 M)-induced contractions (C), and the excitatory neural pathway under non-nitrergic non-purinergic conditions (E). Histograms show the effect of peppermint oil (1–1,000 μg/mL) plus HBB (10–7 to 10–5 M) on spontaneous phasic contractions (B), cch-induced contractions (D), and electrical field stimulation-induced contractions (F) in the circular (left) and longitudinal (right) muscles. Data were normalized (i.e., 100%) to the basal AUC or the electrical field stimulation amplitude before drug addition. Dunnett’s post hoc test was done after ANOVA. # p < 0.05, ## p < 0.01, ### p < 0.001, #### p < 0.0001 compared with basal conditions and *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 compared with peppermint oil 1,000 μg/mL. Data were expressed as mean ± SEM.