| Child-friendly single-tablet fixed dose combination (FDC) regimens are critical for improved adherence and treatment outcomes in HIV-1. There are very few FDC options available for children weighing < 14 kg. |
| The present study modeled the pharmacokinetics (PK) of abacavir (ABC), dolutegravir (DTG), and lamivudine (3TC) after administering a once-daily ABC/DTG/3TC FDC dose (dispersible tablet or tablet) to pediatric participants with HIV-1 in IMPAACT 2019 study. |
| ABC, DTG, and 3TC PK exposures following once-daily ABC/DTG/3TC dispersible tablet and tablet dosing were comparable to those observed in pediatrics and adults with single entities, supporting extrapolation of adult efficacy data. |
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