FIG. 2.

Macroscopic examination of a representative 7-week-old nu/nu rat after 3 weeks of subcutaneous inoculation of F344-S1 cells (a to c) and another representative 14-week-old nu/nu rat after 10 weeks of subcutaneous inoculation of TARS-1 cells (d and e). (a) Note the large tumor at the site of inoculation (solid arrow) and the appearance of several skin rashes (open arrow). (b) Note the hypertrophied axillary lymph node (closed arrow) and several other nodules at the site of skin rashes (open arrow). (c) Metastatic tumors in the lungs (arrow). (d) Note the progressive growth of subcutaneous tumor cells (arrow). (e) Metastatic tumors in the lungs (arrow).