TABLE 3.
In vivo tumorigenicity of a series of FPM1 cell lines
| Cell line | Origin | Recipient (age) | No. of rats | Inoculation routea | Finding(s)b |
|---|---|---|---|---|---|
| FPM1 | In vitro-transformed thymocytes | nu/+ (NBc) | 2 | s.c. | NS |
| nu/nu (NB) | 2 | s.c. | Progressive tumor | ||
| nu/+ (NB) | 5 | i.p. | NS | ||
| nu/nu (NB) | 3 | i.p. | Death (2 wk)d | ||
| nu/nu (4 wk) | 4 | s.c. | Transient tumor | ||
| nu/nu (4 wk) | 2 | i.p. | NS | ||
| FPM1-N2 | s.c. tumor | nu/+ (NB) | 5 | s.c. | NS |
| nu/nu (NB) | 4 | s.c. | Progressive s.c. tumor with metastasis in lymph nodes | ||
| FPM1-V1AX | Axillary lymph node | nu/nu (4 wk) | 6 | s.c. | Progressive s.c. tumor with multiple systemic metastasis |
a
s.c., subcutaneous; i.p., intraperitoneal.
b
Autopsy was performed 2 to 10 weeks after inoculation. NS, no symptoms.
c
NB, newborn.
d
The rats died within 2 weeks after inoculation.