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. 2024 Jul 23;14:16895. doi: 10.1038/s41598-024-66473-4

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SARS-CoV-2 [S1S2] spike induces proteolytic activation of α and γ ENAC in differentiated BCi-NS1.1 (d-BCi) epithelia. ALI differentiated dBCi cells were incubated apically with different concentrations of Wuhan-Hu-1 [S1S2] spike protein for 4 h, washed and then incubated for additional 20 h under ALI conditions. (a) A representative Western blot image showing the detecting levels of total γ ENaC and two proteolytic cleavage products (red arrowheads). (b) A representative Western blot image showing the detecting levels of total α ENaC and its proteolytic cleavage product (red arrowhead). β-actin was used for equal loading of protein. Western blots are representative of the results from three independent experiments.