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Inhibition constants for Wuhan-Hu-1 and β-1.351 [S1S2] spike effects on CFTR channels and CFTR protein, and on binding constants for ACE2.
| Spike variant | Ki, CFTR channel (R2) spike, ng /ml | Ki, CFTR protein (R2) spike, ng /ml |
|---|---|---|
| Wuhan-Hu-1, [S1S2] | 446 (0.9898) | 399 (0.9842) |
| β-1.351 [S1S2] | 210 ((0.9590) | 193 (0.9590) |
|
Ratio, % Wuhan-Hu-1/β-1.351 |
(47%) | (48%) |
