TABLE 3.
Oncological and reproductive outcomes of AH and EC patients undergoing conservative therapy with HR.
| CR | Recurrence | Pregnancy (For all patients) | Pregnancy (For complete responders) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of women/ studies | Estimate (95% CI; %) | I 2 (%) | No. of women/studies | Estimate (95% CI; %) | I 2 (%) | No. of women/ studies | Estimate (95% CI; %) | I 2 (%) | No. of women/ studies | Estimate (95% CI; %) | I 2 (%) | |
| AH | 444/12 | 97.0 [94.7; 98.8] | 48.5% | 419/12 | 10.8 [4.6; 18.6] | 71.7% | ||||||
| EC | 407/21 | 88.6 [84.8; 92.0] | 48.7% | 327/18 | 18.3 [13.7; 23.3] | 44.3% | 252/12 | 32.4 [20.2; 45.9] | 76.2% | 221/12 | 36.7 [23.6; 50.8] | 74.4% |
| Pregnancy (For complete responders who attempted to conceive) | Live birth (For all patients) | Live birth (For complete responders) | Live birth (For complete responders who attempted to conceive) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of women/ studies | Estimate (95% CI; %) | I 2 (%) | No. of women/studies | Estimate (95% CI; %) | I 2 (%) | No. of women/ studies | Estimate (95% CI; %) | I 2 (%) | No. of women /studies | Estimate (95% CI; %) | I 2 (%) | |
| AH | 267/9 | 22.2 [10.8; 35.8] | 76.0% | 250/9 | 23.9 [12.3; 37.4] | 73.1% | ||||||
| EC | 127/11 | 59.6 [43.1; 75.2] | 59.8% | 358/18 | 26.0 [17.3; 35.5] | 65.7% | 307/18 | 30.6 [21.0; 41.0] | 63.0% | 131/12 | 51.9 [37.1; 66.6] | 52.6% |
Abbreviations: AH, atypical hyperplasia; CI, confidence interval; CR, complete response; EC, endometrial cancer.