Table 1.

Performance of model on Training set.

Datasets (Model)	Feature Encoding	Tenfold CV test (before WD)					Tenfold CV test (after WD)
		Acc	Sen	Spe	MCC	AUC	Acc	Sen	Spe	MCC	AUC
ACPmain (SVM)	CPSR	0.761	0.714	0.808	0.526	0.749	0.736	0.711	0.761	0.473	0.801
	HOG-PSSM	0.554	0.328	0.783	0.142	0.607	0.732	0.768	0.696	0.465	0.774
	ProtT5	0.700	0.689	0.710	0.401	0.786	0.737	0.667	0.809	0.480	0.791
	ESM-2	0.652	0.676	0.627	0.304	0.712	0.877	0.872	0.881	0.756	0.945
	F1 + F2	0.668	0.607	0.728	0.339	0.738	0.906	0.913	0.899	0.812	0.986
	F1 + F2 + F3	0.784	0.768	0.801	0.570	0.869	0.768	0.720	0.816	0.539	0.827
	F1 + F2 + F4	0.700	0.689	0.710	0.401	0.786	0.778	0.732	0.824	0.559	0.854
ACPmain (CDF)	CPSR	0.720	0.627	0.813	0.448	0.789	0.730	0.691	0.769	0.463	0.811
	HOG-PSSM	0.739	0.721	0.756	0.480	0.802	0.663	0.634	0.692	0.328	0.711
	ProtT5	0.737	0.716	0.759	0.477	0.823	0.692	0.660	0.724	0.387	0.764
	ESM-2	0.753	0.708	0.797	0.508	0.832	0.914	0.926	0.901	0.833	0.963
	F1 + F2	0.734	0.671	0.797	0.471	0.817	0.964	0.955	0.972	0.930	0.991
	F1 + F2 + F3	0.919	0.916	0.922	0.845	0.974	0.918	0.904	0.932	0.843	0.972
	F1 + F2 + F4	0.972	0.965	0.980	0.947	0.992	0.975	0.961	0.990	0.953	0.994
ACPmain (NB)	CPSR	0.628	0.749	0.507	0.264	0.714	0.681	0.609	0.754	0.366	0.742
	HOG-PSSM	0.604	0.498	0.710	0.212	0.617	0.676	0.580	0.772	0.362	0.756
	ProtT5	0.658	0.730	0.586	0.321	0.719	0.812	0.787	0.768	0.855	0.865
	ESM-2	0.653	0.707	0.599	0.308	0.687	0.792	0.817	0.768	0.587	0.870
	F1 + F2	0.652	0.601	0.702	0.306	0.695	0.830	0.805	0.855	0.663	0.871
	F1 + F2 + F3	0.807	0.839	0.775	0.617	0.881	0.818	0.848	0.788	0.639	0.889
	F1 + F2 + F4	0.839	0.811	0.866	0.681	0.879	0.853	0.829	0.878	0.710	0.893
ACPAlter (SVM)	CPSR	0.901	0.867	0.936	0.805	0.953	0.804	0.608	1.000	0.661	0.944
	HOG-PSSM	0.837	0.813	0.861	0.681	0.909	0.876	0.876	0.876	0.753	0.921
	ProtT5	0.896	0.882	0.910	0.794	0.951	0.903	0.909	0.897	0.807	0.957
	ESM-2	0.916	0.928	0.905	0.834	0.973	0.923	0.910	0.936	0.846	0.973
	F1 + F2	0.886	0.894	0.878	0.773	0.952	0.903	0.885	0.922	0.807	0.972
	F1 + F2 + F3	0.834	0.698	0.970	0.696	0.935	0.871	0.753	0.987	0.762	0.954
	F1 + F2 + F4	0.812	0.640	0.984	0.666	0.942	0.865	0.727	1.000	0.757	0.977
ACPAlter (CDF)	CPSR	0.883	0.848	0.919	0.770	0.955	0.878	0.840	0.915	0.761	0.958
	HOG-PSSM	0.839	0.805	0.872	0.683	0.912	0.832	0.784	0.880	0.669	0.913
	ProtT5	0.907	0.889	0.925	0.816	0.964	0.909	0.889	0.928	0.819	0.967
	ESM-2	0.928	0.954	0.902	0.857	0.979	0.998	0.997	0.999	0.996	1.000
	F1 + F2	0.920	0.897	0.943	0.842	0.974	0.997	0.997	0.996	0.994	1.000
	F1 + F2 + F3	0.968	0.977	0.959	0.936	0.994	0.997	0.996	0.999	0.995	1.000
	F1 + F2 + F4	0.954	0.946	0.963	0.909	0.988	0.998	0.997	0.999	0.996	1.000
ACPAlter (NB)	CPSR	0.800	0.809	0.791	0.602	0.882	0.717	0.533	0.900	0.466	0.760
	HOG-PSSM	0.806	0.758	0.855	0.619	0.886	0.718	0.730	0.705	0.444	0.812
	ProtT5	0.854	0.814	0.893	0.712	0.923	0.736	0.603	0.873	0.497	0.835
	ESM-2	0.862	0.914	0.811	0.729	0.929	0.831	0.833	0.828	0.661	0.917
	F1 + F2	0.853	0.805	0.901	0.711	0.882	0.932	0.867	1.000	0.873	0.933
	F1 + F2 + F3	0.890	0.938	0.842	0.784	0.951	0.898	0.800	1.000	0.814	0.900
	F1 + F2 + F4	0.872	0.832	0.911	0.748	0.904	0.932	0.867	1.000	0.873	0.967
ACP740 (SVM)	CPSR	0.692	0.470	0.921	0.435	0.847	0.811	0.810	0.811	0.624	0.899
	HOG-PSSM	0.753	0.797	0.708	0.509	0.832	0.709	0.750	0.667	0.424	0.811
	ProtT5	0.690	0.470	0.917	0.431	0.850	0.864	0.863	0.866	0.732	0.917
	ESM-2	0.888	0.877	0.900	0.779	0.947	0.946	0.895	1.000	0.898	0.999
	F1 + F2	0.865	0.867	0.863	0.730	0.925	0.941	0.937	0.945	0.888	0.992
	F1 + F2 + F3	0.848	0.823	0.873	0.699	0.892	0.871	0.867	0.876	0.745	0.921
	F1 + F2 + F4	0.868	0.830	0.907	0.743	0.922	0.895	0.893	0.897	0.792	0.948
ACP740 (CDF)	CPSR	0.814	0.793	0.835	0.635	0.898	0.836	0.807	0.866	0.675	0.889
	HOG-PSSM	0.748	0.740	0.756	0.500	0.847	0.757	0.763	0.750	0.519	0.849
	ProtT5	0.968	0.977	0.959	0.936	0.994	0.789	0.793	0.783	0.582	0.882
	ESM-2	0.873	0.870	0.876	0.749	0.939	0.980	0.970	0.990	0.962	0.996
	F1 + F2	0.858	0.860	0.856	0.717	0.930	0.988	0.987	0.990	0.977	1.000
	F1 + F2 + F3	0.875	0.863	0.887	0.753	0.933	0.985	0.977	0.993	0.971	0.999
	F1 + F2 + F4	0.968	0.977	0.959	0.936	0.994	0.992	0.990	0.993	0.983	0.999
ACP740 (NB)	CPSR	0.695	0.520	0.876	0.422	0.753	0.717	0.533	0.900	0.466	0.760
	HOG-PSSM	0.718	0.730	0.705	0.444	0.812	0.718	0.730	0.705	0.444	0.812
	ProtT5	0.736	0.603	0.873	0.497	0.835	0.736	0.603	0.873	0.497	0.835
	ESM-2	0.821	0.760	0.883	0.652	0.852	0.831	0.833	0.828	0.661	0.917
	F1 + F2	0.787	0.713	0.862	0.586	0.821	0.932	0.867	1.000	0.873	0.933
	F1 + F2 + F3	0.836	0.777	0.897	0.681	0.864	0.898	0.800	1.000	0.814	0.900
	F1 + F2 + F4	0.829	0.777	0.883	0.665	0.875	0.932	0.867	1.000	0.873	0.967

Best results highlighted in bold.