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. 2024 Jul 23;14:16902. doi: 10.1038/s41598-024-67305-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Liver sections of rats from different experimental groups. (A) The control group (G1) and (G2) received sildenafil and showed a normal histological features of the liver with no abnormalities. Cords of hepatocytes (H) radiating from the central vein (CV). (B,C) show liver of G3 rats that received CCl₄. (B) Shows sever degenerative changes with distorted histological architecture, vacuolization (circle), congested portal tract vasculature (PT), large inflammatory cells infiltrates (asterisk), and congested sinusoids (arrow). (C) Shows Sever congested central vein (cv), dilated sinusoids (angled arrow), and large inflammatory cells infiltrates (asterisk). (D) G4 received sildenafil and CCl₄ and showed improvement of hepatic architecture with congestions between some hepatocytes (H&E ×100).