FIG. 2.

DNA fragmentation analysis by ELISA (A) and PV production (B) in homogenate supernatants of the forebrains, brain stems, and spinal cords of PV-1 Mahoney-infected TgPVR mice. Nonparalyzed mice (open circles) and paralyzed infected mice (solid circles) are indicated. The threshold value for the ELISA was set as the mean value for two negative controls plus twice the standard error of the mean. The viral titer of each homogenate supernatant was determined by TCID₅₀ measurements on HEp-2c cell cultures (21).