Fig. 4.

Relationship between the dose of leisure-time physical activity duration and the risk of mortality in CKD patients, according to the three-knot cubic spline (10, 50, and 90%). The solid line represents the multivariable adjusted hazard ratios (adjusted for sex, blood urea nitrogen, serum potassium, heart failure, hypertension, anemia, and estimated glomerular filtration rate.), with dashed lines showing that 95% of confidence intervals derive from restricted cubic spline regression with three knots. The ordinate value of the dashed lines across 1.0 indicates no significant difference compared with the reference point (0 min). (A) general CKD patients. (B) patients without cardiovascular disease. (C) patients complicated with cardiovascular disease (complications such as heart failure, coronary heart diseases, or with a history of heart attack).