Table 2.

Univariate and multivariable Cox-regression analysis to evaluate the association between NYHA functional classification and all-cause mortality within men and women with cardiovascular disease.

Model	n	Events	NYHA II		NYHA III/IV
			HR (95% CI)	p-value	HR (95% CI)	p-value
Age-adjusted model men	3419	209	1.62 (1.15–2.29)	0.007	3.92 (2.54–6.06)	0.001
Age-adjusted model women	3840	137	1.50 (1.01–2.22)	0.045	1.58 (0.86–2.89)	0.141
Confounder model men	3419	209	1.59 (1.12–2.27)	0.011	3.64 (2.31–5.71)	0.001
Confounder model women	3840	137	1.49 (1.00–2.21)	0.054	1.41 (0.76–2.62)	0.280

Results are presented using NYHA I as the reference level. Variables included in the confounding model were age at presentation to CCN, diabetes, family history, body mass index and the conclusion of the ECG stress test. HR, hazard ratio; CI, confidence interval.