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. 2024 Jul 1;47:102040. doi: 10.1016/j.tranon.2024.102040

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© 2024 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Changes in protein abundance in regorafenib-resistant cells compared to parental cells.

A. Volcano plot for differential gene expression. B. GO analysis of the DEGs in the MHCC-97H/REGO cohort. C. Heatmap of protein microarray data for cell cycle, EMT and MAPK pathway genes in the MHCC-97H and MHCC-97H/REGO cell lines. d-E. Qualitative and quantitative analysis of the protein expression levels of E-cadherin, N-cadherin, vimentin, snail, cyclin B1, p-ERK and t-ERK in MHCC-97H and MHCC-97H/REGO cells.