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Acetylation in ferroptosis. The acetylation of histones, ALOX, TP53, HSPA5, and HMGB1, orchestrated by acetyltransferases and deacetylases, plays a pivotal role in the regulation of ferroptosis. The promotion or inhibition of protein function by acetylation is indicated by a positive (+) or negative (−) sign, respectively. Ac, acetylation.
