Fig. 7.

Autophagy-mediated degradation in ferroptosis. A. The process of autophagy, including macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). B. Selective autophagy is involved in regulating important players in iron metabolism (e.g., TFRC, ferritin, and SLC40A1), antioxidant system (e.g., GPX4), membrane tension (e.g., CDH2), and lipid metabolism (e.g., ARNTL) in the process of ferroptotic cell death. Furthermore, CTSB and cysteine released by lysosome can promote and inhibit ferroptosis, respectively.