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Disease decline and exacerbations in the natural history of bronchiectasis. a) Trajectory of lung function over time in bronchiectasis. The decline in lung function is associated with the occurrence of both mild/moderate and severe exacerbations. b) Oscillation between stable states and exacerbations over time, the influence of triggers and the impact of protective factors and interventions on maintaining overall lung health and raising the threshold for exacerbations.
