Figure 4.

The peripubertal DHT‐induced mouse model is a non‐obese but insulin‐resistant model of PCOS. a) Experimental design. b) Fat mass (n = 12 Control, 11 DHT, 9 DHT + Flutamide). c) Insulin levels at baseline and 15 min following glucose administration (n = 12, 12, 10). d) Blood glucose levels during oGTT (n = 12, 12, 10). e) HOMA‐IR, calculated from fasted glucose and insulin levels (n = 12, 12, 10). f) Glycosylated hemoglobin levels (HbA1c) (n = 34, 31, 21). Data are presented as means ± SD. n indicates the number of biologically independent samples examined. Statistical analysis was assessed by two‐way ANOVA with Bonferroni's multiple comparison test b–d,f), or Kruskal‐Wallis with Dunn's multiple comparison e) and significant differences were indicated with p values. Source data are provided as a Source Data File.