Table 2.
Twenty-four novel genome-wide significant loci associated with all-cause HF
| rsID | Gene | Chr. | Pos. (hg19) | EA | NEA | EAF | OR (95% CI) | p value |
|---|---|---|---|---|---|---|---|---|
| rs28416760 | INPP5B | 1 | 38409112 | T | A | 0.73 | 1.03 (1.02, 1.04) | 1.40 × 10−8 |
| rs17163313 | MIA3 | 1 | 222799625 | G | T | 0.71 | 1.03 (1.02, 1.04) | 3.54 × 10−8 |
| rs7564469 | ZEB2 | 2 | 145258445 | C | T | 0.16 | 1.04 (1.03, 1.05) | 2.57 × 10−9 |
| rs3820888 | SPATS2L | 2 | 201180023 | C | T | 0.40 | 1.03 (1.02, 1.04) | 1.43 × 10−10 |
| rs6796042 | FOXP1 | 3 | 71530120 | A | G | 0.62 | 1.03 (1.02, 1.04) | 7.35 × 10−9 |
| rs17253722 | SHROOM3 | 4 | 77367287 | G | A | 0.57 | 1.03 (1.02, 1.04) | 4.57 × 10−8 |
| rs6842241 | EDNRA | 4 | 148400819 | A | C | 0.14 | 1.04 (1.02, 1.05) | 4.67 × 10−8 |
| rs72810976 | CPEB4 | 5 | 173309057 | G | A | 0.68 | 1.03 (1.02, 1.04) | 1.05 × 10−8 |
| rs117321970 | FHL5 | 6 | 97071980 | T | C | 0.05 | 1.07 (1.05, 1.10) | 2.81 × 10−8 |
| rs3918226 | NOS3 | 7 | 150690176 | T | C | 0.08 | 1.05 (1.03, 1.07) | 3.54 × 10−8 |
| rs4733328 | NRG1 | 8 | 32259246 | G | A | 0.14 | 1.04 (1.03, 1.05) | 3.44 × 10−8 |
| rs11774829 | RP11-127H5.1 | 8 | 105978368 | T | A | 0.88 | 1.05 (1.03, 1.07) | 3.76 × 10−10 |
| rs7873569 | TMEM245 | 9 | 111796753 | A | T | 0.57 | 1.03 (1.02, 1.04) | 1.61 × 10−8 |
| rs71311904 | BDNF | 11 | 27742447 | C | CCATTT | 0.82 | 1.05 (1.03, 1.06) | 3.32 × 10−9 |
| rs113104597 | CHD4 | 12 | 6703172 | C | T | 0.16 | 1.04 (1.03, 1.05) | 1.21 × 10−8 |
| rs34682944 | DIP2B | 12 | 50982864 | A | G | 0.31 | 1.03 (1.02, 1.05) | 1.07 × 10−8 |
| rs112403212 | SCARB1 | 12 | 125303254 | T | C | 0.14 | 1.05 (1.03, 1.06) | 7.99 × 10−9 |
| rs10161594 | ATP4B | 13 | 114306243 | G | C | 0.14 | 1.04 (1.03, 1.06) | 1.09 × 10−8 |
| rs58472533 | AMN | 14 | 103385634 | G | A | 0.20 | 1.04 (1.03, 1.05) | 5.49 × 10−10 |
| rs17483686 | IREB2 | 15 | 78733390 | T | A | 0.33 | 1.03 (1.02, 1.04) | 1.55 × 10−9 |
| rs11634851 | ABHD17C | 15 | 81028965 | G | C | 0.45 | 1.03 (1.02, 1.04) | 4.87 × 10−8 |
| rs11861290 | CMIP | 16 | 81548522 | A | G | 0.76 | 1.04 (1.03, 1.05) | 2.27 × 10−10 |
| rs11656489 | ADORA2B | 17 | 15837141 | G | C | 0.19 | 1.04 (1.02, 1.05) | 6.15 × 10−9 |
| rs17608766 | GOSR2 | 17 | 45013271 | C | T | 0.15 | 1.04 (1.03, 1.06) | 6.24 × 10−10 |
Gene, gene abbreviation of the gene closest to the sentinel SNP; Chr., chromosome; Pos., position; T2D, type 2 diabetes; HF, heart failure; EA, effect allele; NEA, non-effect allele; EAF, effect allele frequency; OR: odds ratio; CI, confidence interval.
Novel locus: a 1 Mb region around the sentinel SNP (±500 kb) not overlapping with any previously reported genome-wide significant locus (±500 kb region centered around the sentinel SNP of each locus). Only the summary statistics of the sentinel SNPs are reported in the table.