Table 2.
Haplotype analysis at the MAPT locus
| Marker | Genotype | Haplotype |
Cases |
Controls |
χ2A | χ2AA | ||
|---|---|---|---|---|---|---|---|---|
| Count | Freq | Count | Freq | |||||
| chr17:44039691A>G (rs17650901) | G/G | H2/H2 | 163 | 0.04 | 644 | 0.06 | 1.9 × 10−9 | 7.7 × 10−9 |
| G/A | H1/H2 | 1,221 | 0.33 | 4,098 | 0.36 | |||
| A/A | H1/H1 | 2,372 | 0.63 | 6,491 | 0.58 | |||
| chr17:44019712G>A (rs242557) | A/A | H1c/H1c | 509 | 0.14 | 1,338 | 0.12 | 5 × 10−3 | 8.8 × 10−3 |
| A/G | H1/H1c | 1,733 | 0.46 | 5,148 | 0.46 | |||
| G/G | H1/H1 | 1,514 | 0.40 | 4,747 | 0.42 | |||
The H1 and H2 haplotype distribution is shown for cases and controls. Count, number of subjects; freq, frequency of the haplotype.