Table 3.

Ancestry-related difference at the APOE locus

						Minor allele frequency
						Discovery		1000G	Discovery Nordic/Central European		Independent Nordic/Central European cohort	Discovery Mediterranean		Independent Italian cohort
Chr	rs number	Base pair	p value	OR	Allele	Cases	Controls	EUR	Cases	Controls	Controls	Cases	Controls	Controls
19	rs6857	45,392,254	6.22E-10	1.27	T	0.1793	0.1508	0.165	0.1855	0.1651	0.1686	0.1689	0.109	0.1204
19	rs12972970	45,387,596	2.10E-09	1.28	A	0.1531	0.1283	0.1352	0.1598	0.1422	0.147	0.1417	0.0877	0.1026
19	rs34342646	45,388,130	2.35E-09	1.276	A	0.1571	0.1321	0.1392	0.1636	0.1455	0.147	0.146	0.09294	0.1026
19	rs71352238	45,394,336	3.87E-09	1.273	C	0.155	0.1304	0.1332	0.1624	0.1444	0.1527	0.1424	0.08945	0.1033
19	rs2075650	45,395,619	5.29E-09	1.272	G	0.1523	0.128	0.1312	0.1598	0.1427	0.1455	0.1396	0.08491	0.1033
19	rs11556505	45,396,144	5.50E-09	1.272	T	0.1519	0.1278	0.1312	0.1594	0.1426	0.1455	0.1392	0.08456	0.1033

The allele frequencies of the significant markers at the APOE locus are shown in different cohorts (the entire discovery cohort; the 1000 Genomes European cohort, the discovery cohort divided into Central European/Nordic and Mediterranean European populations, and independent samples of Central European/Nordic and Mediterranean European ancestry). 1000G, 1000 Genomes.