Table 4.
Top marker summary statistics for the Central European/Nordic and Mediterranean European cohorts
|
Discovery |
Replication |
Joint Analysis |
|||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Minor allele frequency | PLINK | Minor allele frequency | PLINK | METAL | |||||||||||||||||||||
| Cohort | rs number | Chr | Base pair | Locus | A1/A2 | Controls | Cases | 1000G IBR | 1000G TSI | 1000G GBR | 1000G CEU | OR | Beta | SE | p value | Controls | Cases | OR | Beta | SE | p value | Beta | OR | SE | p value |
| Central European/Nordic | rs199443 | 17 | 44,819,565 | MAPT | T/C | 0.215 | 0.175 | - | - | 0.231 | 0.197 | 1.293 | 0.256 | 0.045 | 1.08E-08 | 0.211 | 0.179 | 1.283 | 0.249 | 0.109 | 2.19E-02 | 0.256 | 1.291 | 0.042 | 8.018E-10 |
| rs6857 | 19 | 45,392,254 | APOE | T/C | 0.165 | 0.186 | - | - | 0.170 | 0.197 | 1.193 | 0.176 | 0.045 | 7.90E-05 | 0.168 | 0.203 | 1.235 | 0.211 | 0.095 | 2.55E-02 | 0.183 | 1.201 | 0.041 | 6.799E-06 | |
| Mediterranean European | rs199443 | 17 | 44,819,565 | MAPT | T/C | 0.250 | 0.207 | 0.262 | 0.308 | - | - | 1.184 | 0.170 | 0.070 | 1.52E-02 | 0.265 | 0.234 | 1.142 | 0.133 | 0.108 | 2.19E-01 | 0.159 | 1.172 | 0.059 | 6.80E-03 |
| rs6857 | 19 | 45,392,254 | APOE | T/C | 0.109 | 0.169 | 0.164 | 0.117 | - | - | 1.457 | 0.376 | 0.082 | 4.00E-06 | 0.124 | 0.165 | 1.281 | 0.248 | 0.126 | 4.88E-02 | 0.338 | 1.402 | 0.068 | 7.67E-07 | |
Discovery, replication, and joint analysis statistics are shown for the top markers (smallest p value) at the significant loci. 1000G, 1000 Genomes MAF; GBR, British in England and Scotland; CEU, Northern Europeans from Utah; IBR, Iberian populations in Spain; TSI, Tuscans from Italy.