Figure 8.

Partitioning GxE heritability across 53 tissue-specific genes

We plot $-lo{g}_{10}\left(p\right)$ where p is the corresponding p value of the tissue-specific GxE enrichment defined as $\frac{h_{gxe,tissue}^2/h_{gxe,total}^2}{M_{tissue}/M_{total}}$. For every tissue-specific annotation, we use GENIE to test whether this annotation is significantly enriched for per-SNP heritability, conditional on 28 functional annotations that are part of the baseline LDSC annotations. The dashed and solid lines correspond to the nominal $p<0.05$ and FDR $<0.1$ threshold, respectively. We have labeled two tissues with the most significant p values for each figure.