FIGURE 2.

Tool compounds for SLCs. (A) Overview of compound (left Y-axis) and assay (right Y-axis) availability for each SLC family. Compound activity refers to the activity for its primary SLC target. (B) Number of potential tool compounds per SLC, visualized on an unrooted tree representation of a hierarchical clustering of similarities between structural models of SLCs. Each node represents an SLC, and its size corresponds to the number of described tool compounds. The nodes are colored by structural folds of the SLCs; MFS, major facilitator superfamily fold (MFS); LeuT, leucine transporter fold; MitC, mitochondrial carrier fold; DMT, drug/metabolite transporter fold; UraA, uracil transporter fold; NhaA, Na+/H+ antiporter fold. Clustering and fold classification as described in Ferrada and SupertiFurga (2022). (C) Interactive dashboard showing the table of all available compounds targeting SLCs filtered for SLC47 family genes. The activity of pyrimethamine targeting SLC47A1 is selected. This SLC is the primary target for this compound, but pyrimethamine is only the third most active compound for this SLC. All four scored target activities for pyrimethamine are displayed in the compound’s panel (lower left), and all 53 scored compound activities for SLC47A1 are displayed in the target gene’s panel (lower right).