TABLE 2.

Potencies of the screened reported and potential tool compounds. Only active values are shown; the full table including literature references can be found in the Supplementary Material. a) values were published previously (Sijben et al., 2021b); b) possibly due to an indirect effect of the assay/cell model; c) as reported in Supplementary Table S2.

Compound name	ChEMBL parent ID	SLC	Assay	Activity type	Activity value	Literature median activityc
DIDS	CHEMBL1162148	SLC1A1	EchoMS	pIC50	5.2
TFB-TBOA	CHEMBL1257519	SLC1A1	EchoMS	pIC50	6.4	6.9
Riluzole	CHEMBL744	SLC1A1	EchoMS	pIC50	5.1
WAY-213613	CHEMBL1628669	SLC1A1	EchoMS	pIC50	5.5	5.7
Loratadine	CHEMBL998	SLC1A1	EchoMS	pIC50	5.7
KPH2f	CHEMBL5222644	SLC1A1	EchoMS	pIC50	6.0
TFB-TBOA	CHEMBL1257519	SLC1A2	EchoMS	pIC50	8.1	7.9
Threo-beta-benzyloxyaspartic acid	CHEMBL475341	SLC1A2	EchoMS	pIC50	5.1	5.7
WAY-213613	CHEMBL1628669	SLC1A2	EchoMS	pIC50	6.6	7.1
TFB-TBOA	CHEMBL1257519	SLC1A3	EchoMS	pIC50	8.1	8.1
UCPH-101	CHEMBL474133	SLC1A3	EchoMS	pIC50	6.3	6.5
UCPH-102	CHEMBL1259233	SLC1A3	EchoMS	pIC50	6.8	6.4
Loratadine	CHEMBL998	SLC1A3	EchoMS	pIC50	5.2
WAY-213613	CHEMBL1628669	SLC6A2	TRACT	pIC50	6
Desipramine	CHEMBL72	SLC6A2	TRACT	pIC50	8.1a	8.7
Vanoxerine (GBR12909)	CHEMBL281594	SLC6A2	TRACT	pIC50	6.1a	6.9
KPH2f	CHEMBL5222644	SLC6A2	TRACT	pIC50	6
Desipramine	CHEMBL72	SLC6A4	Uptake	pIC50	6.3	7.1
Vanoxerine (GBR12909)	CHEMBL281594	SLC6A4	Uptake	pIC50	5.7	6.8
DSP-1053	CHEMBL4226281	SLC6A4	Uptake	pIC50	7.2	8.8
BAY-876	CHEMBL4448899	SLC6A4	Uptake	pEC50	8.1b
KPH2f	CHEMBL5222644	SLC6A4	Uptake	pIC50	6
DSP-1053	CHEMBL4226281	SLC6A12	MP dye	Inhibition (3 µM) [%]	36