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. 2024 Jul 9;19(7):1593–1603. doi: 10.1021/acschembio.4c00244

Figure 1.

Figure 1

Helicase inhibition is a target for blocking viral replication. (A) Simplified overview of SARS-CoV-2 viral replication in the host. (B) Structure of helicase with the location of the RNA and ATP binding sites indicated by purple and orange balls, respectively. Five domains are shown: zinc-binding domain (green); stalk (yellow); subdomain 1B (salmon); subdomain 1A (dark blue); subdomain 2A (light blue). Gray balls represent bound Zn2+. (PDB ID: 6ZSL). (C) Flowchart describing steps employed in virtual screen for Nsp13 inhibitors.