Figure 1.

Helicase inhibition is a target for blocking viral replication. (A) Simplified overview of SARS-CoV-2 viral replication in the host. (B) Structure of helicase with the location of the RNA and ATP binding sites indicated by purple and orange balls, respectively. Five domains are shown: zinc-binding domain (green); stalk (yellow); subdomain 1B (salmon); subdomain 1A (dark blue); subdomain 2A (light blue). Gray balls represent bound Zn²⁺. (PDB ID: 6ZSL). (C) Flowchart describing steps employed in virtual screen for Nsp13 inhibitors.