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. 2024 Jul 23;15:223. doi: 10.1186/s13287-024-03852-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Endoplasmic reticulum (ER) stress during the activation of human scHSCs. (A) Schematic outline of the comparisons made in the mRNA sequencing data. (B) Gene Ontology (GO) terms upregulated (red) and downregulated (blue). Numbers in parentheses show the FDR q-value. NES: Normalized enrichment score. GO: Gene ontology. n = 4 cell lines were sequenced, with N = 3 technical replicates per condition. (C) Heatmap showing the z-score of selected HSC-typical ER stress-related genes from mRNA sequencing data. n = 4 cell lines were sequenced, with N = 3 technical replicates per condition