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. 2024 Jul 24;25(1):120. doi: 10.1186/s10194-024-01807-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Hypothalamic voltage deflection following CSD happens under P2X7R antagonism with an increase in latency to CSD. (a) Schematic representation of cortical and subcortical electrophysiology. (b) Representative traces of cortical (Cx) and subcortical recordings from the striatum (Str), hippocampus (Hc), thalamus (Th) and hypothalamus (Hypoth). (c) Schematic representation of cortical and hypothalamic electrophysiology experimental protocol (green dot: insertion point of tungsten electrode for hypothalamic recordings, pink dot: pin-prick site, grey dot: surface electrode). (d) Representative traces of cortical and hypothalamic recordings in control group or upon P2X7R antagonist administration. (e) Hypothalamic voltage deflection latency to CSD in control group and upon P2X7R antagonist administration (n = 4/group). (f) Representative images of hypothalamic c-fos immunofluorescent staining in naïve mice, after CSD induction and upon P2X7R antagonist administration. scale bar:25 µm (g) c-fos positive cell numbers in hypothalamus of naïve mice, after CSD induction and upon P2X7R antagonist administration (n = 5/group). CSD: Cortical Spreading Depression (ns: p > 0.05, *:p < 0.05, **:p < 0.01, ***:p < 0.001)