Fig 2.

The transcriptional profiles of RHA1 and RHA1-EG. The most highly differentially regulated genes (log2FC > 3, padj <0.0001) are shown together with their associated pathways. Differential expression of genes in RHA1 grown on ethylene glycol (EG) or glycolate (Gly) was compared to acetate (Ac) and Gly-grown cells, respectively. Differential expression of genes in RHA1-EG grown on EG was compared to RHA1 grown on Ac, Gly, and EG. Dark-gray cells indicate missing values in the transcriptome data. MAD, mycofactocin-dependent alcohol degradation; MFT, mycofactocin biosynthesis; ALL, allantoin degradation; GCL1&2, glyoxylate carboligase pathways 1 and 2; GLC, glycolate pathway; ETA, ethanolamine degradation; RuMP1&2, ribulose-monophosphate pathways 1 and 2; MDF, mycothiol-dependent formaldehyde degradation; αβ-CC, αβ-carboxylase containing cluster; FA, fatty acid biosynthesis; TCA, tricarboxylic acid cycle; URA, urate degradation; MEK, methyl ethyl ketone degradation; PROP, propane degradation; PKS, polyketide synthesis; UNK, unknown.