Table 2.
Antibacterial effect (I) and PK/PD parameters of tulathromycin against APP.
| Groups (μg/mL) | Cmax/MIC99 | AUC168 h/MIC99 (h) | %T > MIC99 (%) | I (Log10 CFU/mL) |
|---|---|---|---|---|
| Control | 0.00 | 0.00 | 0.00 | 1.04 |
| 0.7 | 0.56 | 41.20 | 0.00 | −1.88 |
| 1.4 | 0.88 | 89.29 | 0.00 | −3.82 |
| 2.8 | 1.85 | 174.03 | 48.57 | −3.37 |
| 5.6 | 3.70 | 356.86 | 100.00 | −4.48 |
| 11.2 | 7.81 | 620.34 | 100.00 | −5.51 |
| 22.4 | 16.19 | 1425.63 | 100.00 | −7.05 |
| 44.8 | 33.12 | 2492.79 | 100.00 | −6.95 |
AUC0–168 h/MIC99, area under the curve between 0 h to 168 h divided MIC99; Cmax/MIC99, maximum concentration divided MIC99; %T > MIC99, percentage of time that the tulathromycin concentration was above the MIC99 during 168 h. All values were calculated as the mean value of three values.