Table 3.
PK/PD parameters and AUC168 h/MIC99 to achieve different antibacterial effects.
| PK/PD parameters | Values |
|---|---|
| Imax (Log10 CFU/mL) | 1.04 |
| IC50 (h) | 450.92 |
| Imax−I0 (Log10 CFU/mL) | −12.22 |
| Slope (N) | 0.43 |
| AUC168 h/MIC99 for bacteriostatic effect (h) | 1.80 |
| AUC168 h/MIC99 for bactericidal effect (h) | 87.42 |
| AUC168 h/MIC99 for eradication effect (h) | 198.00 |
Imax, maximum antibacterial effect; I0, bacterial change in blank group; IC50, value of AUC0-168 h/MIC99 required to reach half of Imax; N, Hill coefficient, which represents the slope of the curve fitting AUC0–168 h/MIC99 and I.