Skip to main content
. 2024 Jul 1;23:2763–2778. doi: 10.1016/j.csbj.2024.06.036

Table 1.

Parameters applied to the PBK model for PFOS and PFOA.

Input Parameters Values Reference
Integration method Rosenbrock (Stiff) EFSA CONTAM PANEL, 2018 [29]
DT min 1.00E-06 EFSA CONTAM PANEL, 2018 [29]
DT max 10 EFSA CONTAM PANEL, 2018 [29]
DT 0.01 EFSA CONTAM PANEL, 2018 [29]
Tolerance 0.01 EFSA CONTAM PANEL, 2018 [29]
PFOA
Tmc; (µg/h/kg0.75) Maximum resorption rate 6000 EFSA CONTAM PANEL, 2018 [29]
Kt; (µg/L) Resorption affinity 55 EFSA CONTAM PANEL, 2018 [29]
Free; Free fraction of PFOA in plasma 0.02 fit to plasma concentration in monkey (Loccisano et al., 2011)[25]
PL; Liver/plasma partition coefficient 2.2 Kudo et al., 2007 [36]
PF; Fat/plasma partition coefficient 0.04 Kudo et al., 2007 [36]
PK; Kidney/plasma partition coefficient 1.05 Kudo et al., 2007 [36]
PSk; Skin/plasma partition coefficient 0.1 Kudo et al., 2007 [36]
PR; Rest of the body/plasma partition coefficient 0.12 Kudo et al., 2007 [36]
PG; Gut/blood plasma coefficient 0.05 Kudo et al., 2007 [36]
Kurinec;urinary elimination rate constant (/h/kg^−0.25) 0.0003 estimated from Harada et al., (2005) [37]
PFOS
Tmc; (µg/h/kg0.75) Maximum resorption rate 3500 EFSA CONTAM PANEL, 2018 [29]
Kt; (µg/L) Resorption affinity 23 EFSA CONTAM PANEL, 2018 [29]
Free; Free fraction of PFOS in plasma 0.025 fit to plasma concentration in monkey (Loccisano et al. 2011)[25]
PL; Liver/plasma partition coefficient 3.72 de Pierre (Loccisano et al. 2011) [25]
PF; Fat/plasma partition coefficient 0.14 de Pierre (Loccisano et al. 2011) [25]
PK; Kidney/plasma partition coefficient 0.8 de Pierre (Loccisano et al. 2011) [25]
PSk; Skin/plasma partition coefficient 0.29 de Pierre (Loccisano et al. 2011) [25]
PR; Rest of the body/plasma partition coefficient 0.2 de Pierre (Loccisano et al. 2011) [25]
PG; Gut/blood plasma coefficient 0.57 de Pierre (Loccisano et al. 2011) [25]
Kurinec;urinary elimination rate constant (/h/kg^−0.25) 0.001 estimated from Harada et al. (2005) [37]

In the model for PFNA and PFHxS the tissue/blood partition coefficients were adjusted for liver and kidney according to Fragki et al. [26]. In the Table 2, Table 3 the input parameters for PFNA and PFHxS are reported as taken from Fragki et al. [26].