Table 3.

Models parameters to be considered for the PBK model simulations of PFHxS.

PFHxS	Fragki et al. 2023[26]
Tmc; (µg/h/kg0.75) Maximum resorption rate	7000a
Kt; (µg/L) Resorption affinity	23
Free; Free fraction of PFHxS in plasma, based on value for PFOS	0.025
PL; Liver/plasma partition coefficient	0.85b
PF; Fat/plasma partition coefficient, based on value for PFOS	0.14
PK; Kidney/plasma partition coefficient	0.3
PSk; Skin/plasma partition coefficient, based on value for PFOS	0.29c
PR; Rest of the body/plasma partition coefficient, based on value for PFOS	0.2
PG; Gut/blood plasma coefficient	0.57
Kurinec;urinary elimination rate constant (/h/kg^−0.25); based on value for PFOS	0.001

^aCalibrated to result in half-lives of 8.2 years (range: 0.34–20) for PFHxS [27], [28].

^bOriginal reference is [38].

^cOriginal reference is [38].