Table 1.
All patients' characteristics. The table shows the characteristics of all patients participating in the study. The number of patients does not always add up to 100 % (n = 212) due to missing data for some attributes.
A studied cohort of patients | Median age (years) [range] | 60.92 [24–89] |
% |
---|---|---|---|
n = 212 | |||
Tumor type | |||
low-grade serous | 9 | 4.2 | |
high-grade serous | 162 | 76.4 | |
mucinous | 11 | 5.2 | |
clear cell | 9 | 4.2 | |
endometrioid | 4 | 1.9 | |
Brenner | 1 | 0.5 | |
borderline | 1 | 0.5 | |
adenocarcinoma | 4 | 1.9 | |
generalized disease | 1 | 0.5 | |
Grade | |||
1 | 7 | 3.3 | |
2 | 19 | 9.0 | |
3 | 165 | 77.8 | |
FIGO stagea | |||
I | 9 | 4.2 | |
II | 12 | 5.7 | |
III | 156 | 73.6 | |
IV | 15 | 7.1 | |
Residual tumorb | |||
yes | 102 | 48.1 | |
no | 90 | 42.5 | |
BRCA1/BRCA2 mutationc | |||
yes | 13 | 6.1 | |
no | 199 | 93.9 | |
Therapy regimen | |||
paclitaxel + platinum derivatives | 162 | 76.4 | |
platinum monotherapy | 6 | 2.8 | |
other regimend | 10 | 4.7 | |
none | 1 | 0.5 | |
Platinum-based therapy resistance | |||
yes | 60 | 28.3 | |
no | 106 | 50.0 | |
Median platinum-free interval (PFI,months) [range] | |||
platinum-resistant | 5.31 (0–11.5) | ||
platinum-sensitive | 29.06 (12–97) |
FIGO (International Federation of Gynecology and Obstetrics) staging system is used for ovarian, fallopian tube, and peritoneal cancer classification.
Residual tumor after surgery was defined by a surgeon as “yes” (macroscopic lesions <1 cm and peritoneal metastases >1 cm), or “no” [no macroscopic residuum (R)].
Breast cancer 1 and 2 (BRCA1/2) germline mutations are the most frequent causes of developing hereditary OvC.
Other regimen [paclitaxel + platinum derivate + cyclofosfamid, cisplatin + doxorubicin, oxaliplatin + capecitabine (known as XELOX), oxaliplatin + 5-fluorouracil + folinic acid (known as FOLFOX) administered in a regimen called modified FOLFOX6, or paclitaxel + carboplatin + bevacizumab].