Table 3.
Extent of diagnostic work-up that was required to reach a final diagnosis in both study arms.
| Control arm n = 262 (absolute numbers) | Intervention arm n = 264 (absolute numbers) | p-value | |
|---|---|---|---|
| Primary imaging only | 1.1% (3/262) | 27.7% (73/264) | <0.0001c |
| Supplemental imaging | |||
| 1x | 16.4% (43/262) | 8.7% (23/264) | |
| 2x | 43.5% (114/262) | 41.7% (110/264) | |
| 3x | 13.0% (34/262) | 5.7% (15/264) | |
| 4x | 19.5% (51/262) | 14.4% (38/264) | |
| 5x | 5.7% (15/262) | 1.5% (4/264) | |
| 6x | 0.4% (1/262) | 0.0% (0/264) | |
| 7x | 0.0% (0/262) | 0.4% (1/264) | |
| Tissue sampling | 74.4% (195/262)a | 58.3% (154/264)b | <0.0001 |
| Cyst aspiration | 18.3% (48/262) | 2.7% (7/264) | <0.0001 |
| FNAC | 6.9% (18/262) | 1.5% (4/264) | 0.0044 |
| Core needle biopsy | 53.1% (139/262) | 60.6% (150/264) | 0.44 |
NB. In one patient in the control arm, tissue sampling was performed without supplemental imaging (0.4%).
Abbreviations - FNAC: fine needle aspiration cytology.
a
30 patients had two and six patients three different tissue samples taken in the control arm.
b
41 patients had two, nine patients three, and one patient five different tissue samples taken.
c
p-value from Mann–Whitney U test.